ABSTRACT
Objective To explore the nutritional increased risk related factors in esophageal cancer patients after chemoradio‐therapy .Methods Sixty‐eight esophageal cancer patients undergoing concurrent chemoradiotherapy were prospectively investiga‐ted .The patient‐generated subjective global assessment(PG‐SGA) was adopted to grade the nutritional risk .All of the patients re‐ceived early nutrition education and short‐term nutrition support for severe malnutrition ,nutritional status was assessed again at the end of radiotherapy .The patients were divided into the mild‐to‐moderate malnutrition group[PG‐SGA(B)group] and the severe malnutrition group [PG‐SGA(C)group] according to the PG‐SGA score on admission .The body mass ,albumin(Alb) ,hemoglobin (Hb) ,white blood cells ,platelets ,neutrophils ,lymphocytes ,monocytes and other objective nutrition indicators were collected before and after chemoradiation .Results There were 24 cases in the PG‐SGA(B) group and 44 cases in the PG‐SGA(C) group;the gen‐der ,age and ethnic had no statistical differences between the two groups(P>0 .05) .Hb(χ2 =2 .710 ,P=0 .009) and Alb(χ2 =3 .743 ,P=0 .000) before chemoradiotherapy had no statistical difference between the two groups(P>0 .05);Hb and Alb after che‐moradiotherapy in the PG‐SGA(B) group were higher than those in the PG‐SGA(C) group .The body mass index(BMI)before and after chemoradiotherapy had statistically significant difference between the two groups (P<0 .05) .The percentage of body mass decrease in the two groups had no statistical significance (P=0 .487) .The PG‐SGA scores after chemoradiotherapy were positively correlated with the change of Hb ,Alb ,BMI parameters and percentage of weight decrease before and after chemoradiotherapy(rs=0 .240 ,0 .249 ,0 .282 ,0 .447 ,P<0 .05) .Conclusion The poor understanding of malnutrition ,the change of Hb ,Alb ,BMI parame‐ters and percentage of body weight decrease before and after chemoradiotherapy are the nutritional increased risk factors in esopha‐geal cancer patients after chemoradiotherapy .
ABSTRACT
Objective To investigate the relationship between the protein expression of X-ray repair cross-complementing protein 3 (XRCC3) and human 8-hydroxyguanine glycosylase 1 (HOGG1) in esophageal squamous cell carcinoma (ESCC) tissue and the prognosis in ESCC patients after radiotherapy.Methods Immunohistochemical SP method was used to measure the protein expression of XRCC3 and HOGG1 in 171 ESCC tissue samples before radiotherapy.The Kaplan-Meier method was used for survival analysis,and the logrank test was used for analyzing the survival difference between negative and positive samples.The Cox model was used for multivariate prognostic analysis.Results The follow-up rate was 87.2％ ; 140 patients were followed up for at least 1 year,136 patients for at least 2 years,and 129 patients for at least 3 years.XRCC3 was mainly expressed in the nucleus,and HOGG1 was mainly expressed in the nucleus and mitochondria,with a coincidence degree of 72.5％ (x2 =23.94,P =0.000).The patients with positive XRCC3 expression and negative XRCC3 expression had similar short-term responses (x2 =0.98,P =0.614)as well as similar survival rates,and both patient groups had a median survival time of 54 months (x2 =0.17,P =0.683).The patients with positive HOGG1 expression and negative HOGG1 expression had similar short-term responses (x2 =0.26,P =0.880) as well as similar survival rates,and both patient groups had a median survival time of 49 months (x2 =0.08,P =0.780).The multivariate prognostic analysis showed that the response evaluation and tumor length were related to the prognosis of ESCC (x2 =7.99,P =0.005 ; x2 =3.76,P =0.045).Conclusions The protein expression of XRCC3 and HOGG1 may be unrelated to the prognosis of ESCC after radiotherapy.